Polymersome-templated porous and hollow nanogels for dual intracellular delivery

摘要

Intracellular delivery has attracted substantial attention due to applications in medicine and investigations into cellular function. Among the current nanocarrier systems, nanogels are very promising vehicles due to their high stability, tunable bioactivity, and minimized protein adsorption. In particular, the ability to specify hydrogel porosity and chemistry permits size- and charge-dependent control over the influx or efflux of molecules. Furthermore, vesicular nanostructures are capable of encapsulating hydrophilic molecules without requiring chemical modification, allowing the transport of protein therapeutics in their native conformation. A nanogel system with a porous and hollow structure may therefore serve as a platform for the delivery of multiple diverse therapeutic payloads via distinct mechanisms of release.