Silver Nanoparticle-Embedded Polymersome Nanocarriers for the Treatment of Antibiotic-Resistant Infections

摘要

This work has many important implications. A dual-mechanism, concentrated treatment in one particle able to overcome antibiotic resistance would be extremely beneficial in the clinic. Importantly, this treatment does not rely on the discovery of a new pharmaceutical compound, which would be extremely expensive to commercialize. Instead, the efficacy of an existing antibiotic is restored by exploiting a synergistic combination with hydrophobic silver nanoparticles and nano-encapsulation. The absence of effect from the AgPs-Amp is a promising sign for limiting the toxicity from the silver nanoparticles themselves. Finally, the designed particle is also easily customizable, allowing for the potential of personalized infection treatments. The authors envision a scenario where a combination of different antibiotics and/or antimicrobial compounds could be loaded into the AgPs designed to optimally treat a patient's specific infection.