Fabrication of Liposome-Loaded Silk Fibroin Nanofiber Mats by Electrospinning

摘要

Liposome is widely used in biomedical field owing to its remarkable ability of delivery drugs.Thus,the introduction of liposcmal drug delivery systems into tissue engineering scaffolds may result in good effect on tissue regeneration.In this study,we successfully fabricated a novel liposome-loaded SF nanofiber based on the eco-friendly method.The electrospun SF fibers were ribbon-shaped and the liposome-loaded SF nanofibers showed no obvious change compared with the pure silk fibroin nanofibers as showed by scanning electron microscopy (SEM).While the Fourier Transform Infrares (FTIR) spectra showed some difference between pure SF nanofibers and Liposome loaded SF nanofibers.Transmission electron microscopy (TEM) showed that liposome distributed on the liposome-loaded SF nanofibers.This novel liposome loaded SF nanofiber mats can be a promising biomaterial in tissue engineering and universally used in medical field.