Non-destructive real-time monitoring of brain tumor exception by combining high-frequency ultrasounds with infrared spectroscopy

摘要

The purpose of the current paper is the development of a non-destructive imaging system for diagnostic purposes,consisting of ultrasonic transducers of high frequency and an infrared spectrometer, enabling the monitoring ofthe brain spatial variation and the detection of cancerous cells spreading to healthy tissues during the neurosurgicaltumor exception. Ultrasound utilization during the neurosurgery, where a part of the skull is temporarilyremoved, is able to provide a new perspective on the imaging techniques. The proposed device combines transducersof different center frequencies in order to achieve sufficient penetration depth inside the brain and nespatial resolution. Moreover, the infrared spectroscopy technique is utilized and combined with the ultrasoundto achieve the recognition of the cancerous cells from their infrared fingerprint. The drawback of the poorpenetration depth of the infrared electromagnetic waves is overcome by inserting a small diameter probe nearthe location of the main tumor. The probe is integrated into the same structure as the ultrasound device toreceive both signals from the identical spot. Finally, advanced signal processing techniques are used to maximizeseparately the information of the independent systems, while the data fusion will be attempted.