Utilizing Oxygen-Inhibited Photopolymerization to Control Size of Multimodal.PEGDA Hydrogel Nanoparticles for Cancer Therapeutics

摘要

Cancer is a class of diseases characterized by hyperproliferative cell growth.Although there are many treatment options for cancer,it has been shown that the use of various modalities at the same time is a more effective treatment than sequentially applying the same modalities.Combining chemotherapy and immunotherapy agents in a nanoparticle equipped with targeting abilities has been shown to facilitate the elimination of cancerous tumors without the need of invasive surgery.Poly(ethylene glycol)diacrylate(PEGDA)hydrogel nanoparticles are of particular interest because of their biocompatibility,non-immunogenity,resistance to protein adsorption,and adjustable mechanical and chemical properties.One of the advantages of PEGDA includes its ability to be photopolymerized,which,consequently,provides increased spatial and temporal control over the hydrogel formation process.