Bioabsorbable Anti-inflammatory Material: A Novel Protein-Conjugated Polymer with Applications in the Implantable Medical Device Field

摘要

In this paper, we present a microfluidic method of creating hybrid protein-PLGA particles. We are combining the bioabsorbable property of PLGA and the anti-inflammatory property of an immunomodulatory protein. We aim to assess whether this protein can inhibit inflammatory response to PLGA's acidic subunits as it degrades. Particles are made using a double emulsion and solvent extraction process. To date, our microfluidic system has been optimized to create single or multi-cavity particles, thin shell particles, and solid particles using a non-toxic solvent. In the near future we will characterize and compare the release profiles of the hybrid protein-PLGA particles vs. conventional protein encapsulated particles.