The Assessment of Toxicity of Boron Nitride Nanoparticle Using Atomic Forced Microscopy

摘要

Nanoparticles have considerably found practical applications in the field of biomedical engineering in recent years. The large surface to volume ratio and the flexibility to deliver in desired positions make them special than any other nanomaterials. However, before being used in human body, the toxicity of Boron nitride nanoparticle (BN NP) must be evaluated. The upake of nanoparticles was confirmed using confocal imaging. Then the stiffness of both normal and cell cultured with BN nanoparticles, were compared using Atomic forced microscopy (AFM). The idea is to observe whether the particles alter the structural integrity of cells by changing their stiffness.