Research on the Intervention Effect of Polydatin of Hyperlipidemia Rats' Early Atherosclerosis

摘要

Purpose: to discuss the function of polydatin on regulating blood-lipid and anti-atherosclerosis. Method: feed rats with high-fat diet to establish early atherosclerosis model, after the model is established successfully, feed with high, medium and low dose of polydatin (160, 80, 40mg·kg~(-1)·d~(-1)), 8 weeks later, measure the rats' serum cholesterol (TC), triglyceride (TG), HDL-Cholesterol (HDL-C), LDL-Cholesterol (LDL-C), tumor necrosis factor (TNF-α), nitric oxide (NO) and inducible nitric oxide synthase (iNOS); take thoracic aorta to carry out oil red O dying to observe the deposition of aortic intimal lipid; take live to make regular HE dying to observe hepatic pathological changes. Result: high, medium and low dosage of polydatin can obviously reduce hyperlipidemia rats' serum TC, TG, LDL-C, TNF-α, NO level and iNOS activity, improve HDL-C level, the difference is statistically significant (P <0.05). Meanwhile, polydatin can decrease the intraaortic leather fat deposition, improve the fatty degeneration and inflammatory cell infiltration of liver. Conclusion: polydatin has functions on regulating blood fat, decreasing the happen of atherosclerosis. This function may relate with its adjust NO and the formation of synthase.