Characterization and Synthesis of a pH Responsive Polymeric Drug Delivery System

摘要

In this study, we report the computation analysis and synthesis of folate functionalized poly(styrene-alt-maleic anhydride), PSMA. Folate was attached to the pH responsive SMA polymer via a biodegradable linker 2,4-diaminobutyric acid, DABA. To examine the linearity of the folate functionalized polymers, computational studies were used. Specifically, trimers were chosen to be the polymer length and the DFT-B3LYP/6-31G basis set was selected as the level of theory. The synthesis was also tested in multi-step experimental procedures. The structures were characterized using IR and NMR.