Effect of Vaccinium dunalianum Glycoside on Platelet Aggregation in Animals

摘要

1-O-(p-hydroxyphenyl)-6-O-caffeoyl-β-D-glucoside (PPCG) was isolated in extraordinary high yield from the dried buds of Vaccinium dunalianum. The present study was aimed to investigate the effect of PPCG on platelet aggregation in animals. In in vitro tests, PPCG showed an inhibitory effect on ADP/PAF-induced platelet aggregation. PPCG significantly prolonged the mice bleeding and clotting time. PPCG (100 and 200 mg/kg) dose dependently reduced mortality of ADP-induced acute pulmonary thromboembolism mice to 80% and 70%, respectively, a high dose (200 mg/kg) of that can reduce serum TC and TG levels of the experimental hyperlipidemia animals, but cannot lower blood viscosity. The observations provide a scientific basis for traditional use of this plant for the treatment of articular rheumatism. Furthermore, these results also suggested that PPCG had anti-thromboembolic effects and good prospects for drug development of cardio-cerebral vascular diseases.