Comorbidità depressione-diabete: differenze di genere in termini di sintomatologia, qualità di vita e personalità.

摘要

Comorbidity between depression and type 2 diabetes mellitus is a particularly common condition as underdiagnosed: 11% to 31% of patients with diabetes have depression or clinically significant depressive symptoms, but depression is not recognized in the 50-75 % of cases. Individuals with diabetes have about a 2-fold increased risk for major depression, affecting one of every 10 diabetic patients. The association between depression and diabetes may be due to biologic effects of depression on the hypothalamic-pituitary axis, platelet adhesion, inflammation or the autonomic nervous system; alternatively, the association may be due to non-adherence with medication leading to hyperglycemia, poorer glycaemic control, worse outcomes, worse quality of life, increased healthcare consumption, complications (particularly significant in females, which is greater also the mortality rate for cardiovascular diseases), increased mortality. The aim of this study is to check the comorbid depression and diabetes and is to correlate depressive symptoms with mental health index and personality variables, especially in females.