Preparation and Drug Release Properties of IBU-loaded Mesoporous Calcium Silicate Hydrate(CSH) spheres

摘要

The novel kind flowerlike mesoporous spheres of calcium silicate hydrate (CaO·SiO_2·H_2O, CSH) have been synthesized by co-precipitation method on based with water/alcohol/calvital/tetraethyl orthosilicate (TEOS) system. The synthesized CSH were applied as a carrier to study the loaded behaviors of ibuprofen(IBU), was used to investigate the drug loading behavior of the CSH for different times has been also discussed. The drug loading capacities(DLCs) of CSH loaded for 12h has reached 116.78wt.%. The structural, morphological and textural properties were investigated by SEM, FTIR, TG and BET. The results show that it would be a good candidate as drug carrier for bone repair.