Fabrication of Minimally-Invasive Patch Type Glucose Sensors

摘要

A fine tube type glucose sensor, which has a sensing region at the inside wall of fine tube tip, was prepared and applied for minimally invasive glucose monitoring. The enzyme glucose oxidase was immobilized on the platinum surface located in the tube by the combination of electrodeposition and electro-polymerization of o-phenylenediamine. Amperometric responses of the prepared electrodes to glucose were measured at a potential of 0.60 V (vs Ag/AgCl). The tube type electrode showed good response with good linear relationship up to the glucose concentration of 22.4 mM, which was actually higher than normal sensor without outer film for permeability restriction. This may be due to its unique sensor structure.