Effect of geometry and size of micro- and nanotopography in the differentiation of human mesenchymal stem cell into endothelial-like cells for vascular repair

摘要

The increase percentage of CD133, CD34 and VEGFR2 expressing cell population and the formation of tubular structures in the Matrigel assay suggest that the synergistic provision of topographical and VEGF induction would possibly induce hMSCs differentiation into vasculogenic cells. Taken together, these findings provided a better understanding on biomimicking in vitro stem cell niche with topographical pattern and biochemical cues, which can be applied in deriving endothelial-like cell as a potential therapeutic cell source for vascular repair.