Biologically-inspired nanofibers for scaffold-mediated gene knockdown to direct stem cell fate

摘要

This study demonstrated the feasibility of PD-coated nanofiber scaffolds for enhanced cellular uptake and the potential platform in utilizing gene silencing to direct stem cell fate. Further studies focusing on other targets (e.g. REST) are currently ongoing to evaluate the efficacy of the platform for enhancing neuronal differentiation in stem cells.