Anti-Fibrotic Roles of Oviductus Ranae in Rats with Hepatic Fibrosis

摘要

In this paper, we focus on the role of Oviductus ranae in protecting the liver against fibrogenesis caused by chemical model in rats and to further explore the underlying mechanisms. Rat models of experimental hepatic fibrosis were established by injection with carbon tetrachloride (CCl4). Optical injection, the denaturation and necrosis level of hepatocytes and the distribution of collagen fibrosis increased obviously after hypodermic injection of CCl4 for 9 weeks. Electron microscope, the shape and structure of cell organells were destroyed obviously. Fat storing cells and kuppfer.s cells increased. Collagen fibrosis distributed extensively in the model groups. After 8 weeks treated with Oviductus ranae. The pathological changes and the collagen fibrosis related with hepatic fibrosis decreased significantly. Conclusions: Oviductus ranae can decrease the pathological changes of hepatic fibrosis induced by CCl4, and prevent the development of hepatic fibrosis.