Monoamine oxidase inhibitory activity of the total alkaloid and organic acid from Chinese herbal medicines

机译：单胺氧化酶的总生物碱和中草药的总生物碱和有机酸的抑制活性

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The aim of this study was to search for potential monoamine oxidase (MAO) inhibitors from Chinese herbal medicine. The organic acid extracts of 34 and the total alkaloidal extracts of 30 traditional Chinese medicines were tested for their MAO inhibitory activities. The results showed that the organic acid extracts of Liquidambar formosana, Pharbitis nil, Punica granatum and alkaloid extracts of Coptis chinensis exhibited the most potent inhibition on MAO and their concentration that inhibited 50% of MAO activity (IC50) values less than 10μg/mL.

机译：本研究的目的是寻找来自中草药的潜在单胺氧化酶（MAO）抑制剂。 34的有机酸提取物和30种中药总量提取物的含量造成毛泽东抑制活性。结果表明，CoptisChinensis的液体蛋白甲型，嗜患者甲酚，苯芽孢子，Pharbitis，丘脑和生物碱提取物的有机酸提取物表现出对MAO的最有效的抑制及其抑制50％的MAO活性（IC 50）值小于10μg/ mL。

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《International Conference on Chemical Engineering and Advanced Materials》|2013年||共4页
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Zhongduo Yang; Jin Ren; Zongmei Shu;
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中图分类 TQ-53;
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Chinese herbal medicine; MAO inhibitors; Organic acid; Alkaloid;

机译：中草药;毛抑制剂;有机酸;生物碱;

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1. Acetylcholinesterase inhibitory activity of the total alkaloid from traditional Chinese herbal medicine for treating Alzheimer’s disease [J] . Zhongduo Yang, Dongbo Zhang, Jin Ren, Medicinal Chemistry Research . 2012,第6期

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2. Acetylcholinesterase inhibitory activity of the total alkaloid from traditional Chinese herbal medicine for treating Alzheimer's disease [J] . Zhongduo Yang, Dongbo Zhang, Jin Ren, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2012,第6期

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3. Monoamine oxidase inhibitory naphthoquinone and/or naphthalene dimers from Lemuni Hitam (Diospyros sp.), a Malaysian herbal medicine. [J] . Okuyama E, Homma M, Satoh Y, Chemical and Pharmaceutical Bulletin . 1999,第10期

机译：来自马来西亚草药Lemuni Hitam（Diospyros sp。）的单胺氧化酶抑制萘醌和/或萘二聚体。
4. Monoamine oxidase inhibitory activity of the total alkaloid and organic acid from Chinese herbal medicines [C] . Zhongduo Yang, Jin Ren, Zongmei Shu International Conference on Chemical Engineering and Advanced Materials . 2013

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6. Effect of Alkaloids Isolated from Phyllodium pulchellum on Monoamine Levels and Monoamine Oxidase Activity in Rat Brain [O] . Lu Cai, Chao Wang, Xiao-kui Huo, 2016

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7. Synthesis of Amide and Ester Derivatives of Cinnamic Acid and Its Analogs: Evaluation of Their Free Radical Scavenging and Monoamine Oxidase and Cholinesterase Inhibitory Activities [O] . 高尾浩一, 十田一宏, 斎藤孝之, 2017

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Monoamine oxidase inhibitory activity of the total alkaloid and organic acid from Chinese herbal medicines

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