Clathrochelate complexes as promising molecular scaffolds for novel biomimetic systems, (radio) pharmaceuticals and topological drugs

摘要

The applicability of the clathrochelates as the biomimetic systems, (radio)pharma-ceuticals and topological drugs as well as an inhibition of the model enzymes (RNA polymerase and topoisomerase) by these complexes are discussed.The modern approach to the pharmaceutical screening is based on several paradigms and empirical rules. They limit the chemical compounds that have a potential as pharmaceuticals for diagnostics and therapy; many chemical systems and classes have been excluded from the routine screening studies and, therefore, are terra incognita for biochemists, pharmacologists, and clinicians. For example, one of the Lipinski's rules [1] states that the molecular weight of the chemical compounds that can be used for pharmaceutical screening should be under 500 Da. The biological activity of these low-weight compounds, constituting up to 90% of the pharmaceutical market (by nomenclature), in most cases is governed by their interactions with biological targets via either covalent or supramolecular bonding.