Multimodality therapy: Enhancement of melanoma cell death with combination of heat shock protein 90 inhibitor, 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG), and gold nanoparticles in a noninvasive radiofrequency field

摘要

Melanoma is the most serious form of skin cancer. Hyperthermia has been attempted as a viable option to treat advanced stage melanoma. However, solid tumors often respond minimally to hyperthermic treatment partly due to the thermo-tolerance induced by chaperons of the heat shock protein family (Hsp). 17-AAG, a Hsp90 inhibitor, is currently being studied in clinical trials as a direct cancer therapeutic agent. We have shown that gold nanoparticles heat cancer cells in a noninvasive radio frequency (RF) field. Here, we demonstrate the enhancement of melanoma cell death with the tandem treatment based on Hsp90 inhibition and heat therapy using gold nanoparticles in a noninvasive RF field.