Synthesis of a New Water-Soluble Conjugated polymers Containing Thiazoline Moiety for Antibacterial Activity Bioassay

摘要

The water-soluble cationic polyfluorene derivatives PFP-N(Me)_3~+I~- and PFP-T containing the thiazoline cycle on side chain was designed and synthesized. The preliminary bioassay was carried out for the thiazolines and polymers at different concentrations. The antibacterial activity of the polymers and thiazolines were determined with E.coli by growth inhibition assays. The results demonstrate that the polymer containing thiazoline cycle (PFP-T) has a higher inhibition ratio against E.coli than the thiazoline compound itself and the corresponding thiazoline quaternary ammonium.