OUTCOME

摘要

Both sessions of the second day focused on correlation of antibody testing results and transplant outcome. The first session started with a discussion of the autoimmune and alloimmune responses in transplant outcome and the correlation with detection of non-HLA specific antibodies as well as donor HLA specific antibodies (DHSA). Dr. Mohanakumar presented studies of chronic rejection in lung transplant, defined clinically as bronchiolitis obliterans syndrome (BOS). They followed the post-transplant development of HLA specific antibodies as well as antibodies to self antigens, K a 1 tubulin and collagen V. The authors observed that the development of donor HLA specific antibodies preceded the development of BOS. Further, these patients also developed antibodies to the self antigens, which persisted even if there were no detectable DHSA. Antibodies to the self antigens myosin, collagen V, and vimentin were found increased with antibody mediated rejection (AMR) in cardiac transplantation. Antibodies to collagen IV and vimentin were found increased with chronic changes in kidney transplantation.