Predicting Non-protein-coding RNA Genes in Escherichia Coli Using SVM with Signature Descriptor

摘要

Non-protein-coding RNA (ncRNA) genes are known to play significant roles. Alongwith transfer RNAs, ribosomal RNAs and mRNAs, ncRNAs contribute to gene splicing, nucleotidemodification, protein transport and regulation of gene expression. Several methods exist for pre-dicting ncRNA genes in Escherichia coli (E.coli). In this paper, we describe a very general, high-throughput method for predicting ncRNA genes in E.coli. The method predicts more than twohundred intergenic regions to contain ncRNA genes, and over half of these overlap with previoustested candidates. Our results indicate that the number of ncRNA genes in E.coli is larger than whathas previously been estimated.