Chitosan-Nanoparticles as UV Filter and Carrier for Cosmetic Actives

摘要

Chitosan derivative was prepared by grafting both phthaloyl groups and methoxy poly(ethylene glycol) moieties onto the polymer chain. Nanoparticles of the prepared chitosan derivative could then be obtained using solvent displacement technique. The products are stable white particles with the average size of 40-150 nm (dry particles). UV screening property, antimicrobial activity and stability of the particles were investigated. Various cosmetic actives such as ethylhexyl-p-methoxycinnamate, ascorbyl palmitate and astaxanthin could be successfully encapsulated into these chitosan-nanoparticles. Encapsulated cosmetic active showed significantly improved photostability comparing to the un-encapsulated compound.