NOVEL PARTICLE SEPARATION USING SPIRAL CHANNEL AND CENTRIFUGAL FORCE FOR PLASMA PREPARATION FROM WHOLE BLOOD

摘要

A device for separating particles from fluid on CD was suggested and studied. Spiral channel displaces particles to the wall of microchannel and transports the solution to the outlet chamber simultaneously. Modeling and analysis of particle movement in liquid implied that the separation can be done within 2 minutes due to the shorter travel length than the conventional centrifuge system. 8 spiral channels were fabricated in 4" disk using PDMS and filtering particles was tested with 5um bead solution. Rotating speed less than 1500 rpm pushed out the solution within 2 minutes and most of particles were separated, even though some of them were also found in fluid chamber due to the structure of branch at the end of channel. Consequently, this paper verified the feasibility of new separation device implemented in centrifugally pumped microfluidic system.