Detection and Charaterization of Stomach Cancer and Atrophic Gastritis with Fluorescence and Raman Spectroscopy

摘要

In this paper, we attempt to find a valid method to distinguish gastric cancer and atrophic gastritis. Auto-fluorescence and Raman spectroscopy of laser induced (514.5nm and 488.0nm) was measured. The serum spectrum is different between normal and cancer. Average value of diagnosis parameter for normal serum, red shift is less than 12nm and Raman relative intensity of peak C by 514.5nm excited is stronger than that of 488.0nm. To gastric cancer, its red shift of average is bigger than 12nm and relative intensity of Raman peak C by 514.5nm excited is weaker than that by 488.0nm. To atrophic gastritis, the distribution state of Raman peaks is similar with normal serum and auto-fluorescence spectrum's shape is similar to that of gastric cancer. Its average Raman peak red shift is bigger than 12nm and the relative intensity of peak C by 514.5 excited is stronger than that of by 488.0. We considered it as a criterion and got an accuracy of 85.6% for diagnosis of gastric cancer compared with the result of clinical diagnosis.