Clinical Investigation of Hospital - Associated Outspread of Severe Acute Respiratory Syndrome

摘要

Objective To summarize and analyze the clinical manifestation, diagnosis and ad-ministrational strategy of severe acute respiratory syndrome (SARS), and its characteristics of outbreak in hospital via infectious transmission cluster associated with SARS cases. Methods (1) Analyze two out - hospital - imported SARS cases with their clinical data and epidemiologically linked transmission clusters in our hospital; (2) summarize the clinical data from 41 SARS cases. Results (1) The transmission capacity of SARS virus in SARS patients is extremely strong, especially in their acute stage; (2) The majority of clinical manifestations were febrile (100% cases), and there were no obvious respiratory symptoms in more than half of patients (53.7%) in early SARS stage (day 1 to day 3) with the number of peripheral white blood cells less than normal (52.6%) and lymphopenia (68.4%) ; (3) It is of a certain of effectiveness for control SARS further development if administrated with Ribavirin, interfer-on - α2b, methylprednisolone, immunoenhancer (such as thymosin - α1) to SARS patients in time. Conclusion It is very important for clinicians to pay much more attention on protectiveness themselves from SARS. It would be very helpful for improving patient's prognosis and under control the SARS overspread if the SARS patients were found, isolated, and treated in time in its early stage.