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Oxygen and oxygenation in the newborn period - Do we know what we are doing?

机译:新生儿时期的氧气和氧气 - 我们知道我们在做什么吗?

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Scheele and Priestly discovered oxygen independently of each other in 1772 and 1774, and it was quickly realized that this gas is not only lifegiving but might be poisonous as well. However, what man has known for only two centuries nature itself has known for some 700 million year. One of the biggest leaps forward in evolution occurred when blue green like algae developed enzymes that scavenge the superoxide radical enabling them to live in an oxygen rich atmosphere. Oxygen therapy for newborn infants was introduced in the USA in the 1930's and 1940's although the Finnish pediatrician Ylppo had already recommended intragastric administration of oxygen in 1917, a practice that continued a surprisingly long time, into the mid-1950's. Not before the discovery of its relation to retrolental fibroplasia (retinopathy of prematurity-ROP) were questions raised concerning the use of oxygen. The rest of the story is well known: in the 1950's and 60's the oxygen concentration was turned down in many incubators apparently resulting in a reduction in ROP but probably increased mortality.
机译:在1772年和1774年,SCHEELE和祭司独立于彼此发现的氧气,并且很快意识到这种气体不仅救生,而且可能是有毒的。但是,只有两个世纪的自然只知道什么人为7亿日。当藻类如藻类如藻类这样的藻类发生时,进化中最大的跳跃之一就会出现,使其使它们能够生活在富氧气氛中的酶活性。在1930年代和1940年代,美国在美国推出了新生儿婴幼儿的氧疗法虽然芬兰儿科医生YLPPO已经推荐了1917年的胃胆氧气给药,这是一个令人惊讶的时间持续令人惊讶的时间,进入1950年代中期。在发现其与翻转纤维形成的关系(早熟 - ROP的视网膜病变)是关于使用氧气的问题。其余的故事是众所周知的:在20世纪50年代,60年代,氧气浓度在许多培养箱中拒绝显然导致ROP减少但可能增加死亡率。

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