During the past few decades, a number of man-made materials and devices have been introduced to restore lost tooth structure in humans. It still remains unclear, whether there can be a replacement material or device suitable for every clinical situation, with minimal or no risk. Traditionally dental restorations are based on in-vitro physical characterization techniques that compare dental structures with restorative material. These testing methods are not able to sample individual structural components. Therefore represents material properties as a single numerical value, which is a large volumetric average of the regional tissues. Though past studies have highlighted anisotropy in dental structures, there are few attempts made to understand the complexity in the property gradients in natural tooth. Such studies will enable the dental researchers to approximate the demands placed on artificial restorative biomaterials during function. Furthermore, when the isotropic artificial biomaterials are used to restore anisotropic dental structure, mismatch between the material properties of the dentine and the restorative material consistently results~(1). This lack of functional harmony between the restoration or device and the remaining tooth structure leads to the rocking of the restoration and loss of marginal integrity at the tooth-restoration interface, which is an established potential source of failure in restorative dentistry [1].
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