Discrete flow microfluidic devices have been identified as a technology that can be used to efficiently deliver health care services by reducing the cycle times and reagent consumption of common biological protocols and medical diagnostic procedures while reducing overhead costs by performing these applications at the point of care. Electrowetting on dielectric is one promising discrete flow microfluidic platform that can individually create, manipulate, and mix droplets through the application of asymmetric electric fields. The work presented outlines fundamental and practical contributions to the understanding and advancement of electrowetting on dielectric devices that the authors are using to develop a device capable of performing immunoassays on chip. Explicit analytical models for capillary force and the reduction in that force by contact angle hysteresis as a function of the three-dimensional shape of the droplet were derived to develop an empirically validated analytical model for transient motion of droplets in electrowetting on dielectric devices.
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