Ultrastructural evaluation of CaD2 mouse mammary carcinoma after photodynamic therapy with meso-tetra(hydroxyphenyl)porphyrin (m-THPP) or its corresponding chlorin (m-THPC)

摘要

The ultrastructural changes that occurred in CaD2 mouse mammary carcinoma at 1, 24, and 96 h after photodynamic therapy (PDT) with meso-tetra(m-hydroxyphenyl)porphyrin (m-THPP, 5 mg/kg b.w.) or its corresponding chlorin (m-THPC, 1 mg/kg b.w.) were investigated. The destruction of the tumors occurred at a faster rate and was more severe by m-THPC-PDT than m-THPP-PDT, although the dose of m-THPC used was 5 times lower than that of m-THPP. The ultrastructral alterations of the tumors after PDT with m-THPP or m-THPC were qualitatively similar: direct damage to both microvasculature and neoplastic cells of the tumors.