PDMS-free modular plugplay construction kit for the development of micro-physiological systems

摘要

Micro-physiological platforms (organ-on-chip, multi-organ-chip) have an enormous potential to strengthen research in drug development, toxicological screening, personalized medicine and disease modeling. The design of such micro-physiological systems (MPS) is an interdisciplinary challenge. We designed a modular plug & play construction kit for the development of MPS. The modular system provides a large number of functional, miniaturized modules such as pumps, oxygenators, reservoirs and cell culture compartments whose fluidic interfaces comply with the luer-lock standard. This allows the modules to be combined quickly and easily with each other, according to the intended application. Depending on their functionality, the modules are implemented using the multilayer technology established at the IWS or modern 3D printing processes. The construction kit also provides a universal control platform. This consists of a basic controller for micro pumps and valves which can be combined with numerous additional modules like gas mixers, oxygenators and pH sensors. Thus, the financial and time expenditure of an MPS development can be drastically reduced with the help of the modular system.