Synthesis and Characterization of Diranitidinecopper(II) Sulfate Dihydrate

摘要

The complex of ranitidine with Cu(II) has been synthesized in l:2-mole ratio of metal to the ligand in water. The forming of the complex was indicated by shifting of maximum wavelength from 816 nm (CuSO4SH2O) to 626 nm (the complex). Infrared spectra indicated NO2 and NH functional group were coordinated to Cu(II). The percentage of copper in the complex measured by Atomic Absorption Spectroscopy (AAS) analysis was 7.5% indicating that formula of the complex was Cu(ranitidine)2S04(H20)n (n=2, 3 or 4). The electrical conductivity of Cu(II) complex in water was 71.0 Scm~(2)mol~(-1) corresponding to 1:1 electrolytes. Thermogravimetric/Differential Thermal Analysis (TG/DTA) showed the presence of two molecules of H2O in the complex. UV-Vis spectra showed a transition peak on 15974 cm~(-1) indicating square planar geometry. The complex was paramagnetic with μ_(eff) 1-77 BM. The proposed formula of the complex was [Cu(ranitidine)2]SO4-2H2O.