Conductive Nanofiber Scaffold for Bone Tissue Engineering

摘要

In order to fabricate nanofiber scaffold for bone tissue engineering, electrospinning technique was employed. This technique produces nanofiberous scaffold supporting cell adhesion, migration, and proliferation. Here, we developed a novel conductive scaffold from poly-caprolactone, gelatin, and poly aniline/graphene nanoparticles. In this study, co-electrospinning was utilized to fabricate composite electrospun scaffold. The effect of polyaniline/graphene (PAG) nanoparticles on the mechanical properties and electrical conductivity of this hybrid scaffold was investigated. The result showed that PAG nanoparticles enbance both mechanical properties and electrical conductivity of the scaffolds. The biocompatibility of the scaffold evaluated by culturing rat bone marrow-derived mesenchymal stem cells (BMSCs) on the scaffolds indicated that the fabricated hybrid nanofiber scaffold supported BMSCs adhesion and proliferation.