Volumetric imaging of the intraocular propagation medium using differential OTF wavefront sensing

摘要

Differential OTF (dOTF) is is a new image-based non-iterative technique for measuring the complex pupil field. When used with a collection of point sources that exhibit position-dependent PSFs, dOTF allows the 3-D tomographic reconstruction of transmission and aberrating structures between the source and the camera. We explore the potential of using dOTF with a pattern of laser spots projected onto the retina to map the 3-D complex transmission between the cornea to some distance into the vitreous. We present the concept, systems-level analysis, simulations, and initial laboratory experiments to validate this approach.