Nanoparticulate Systems of Acyclovir for Topical use in Herpes treatment - Formulation, Characterization and Evaluation

摘要

Of the numerous drugs that are available for systemic treatment of HSV infection, a cream containing an antiviral agent is still the most convenient method of treating herpes simplex labialis/facialis in the general population. Acyclovir (ACV) is a synthetic purine nucleoside analog derived from guanine indicated for the treatment of infections caused by the herpes virus and is considered the safest and most efficacious for this purpose. Topical application of ACV in polyethylene glycol (PEG) is a common practice, but has been shown to be less effective compared to oral and intravenous routes. Considering these aspects, development of ACV-loaded Solid Lipid Nanoparticulate (SLN) drug delivery system by transdermal route was attempted for possible improvement in the permeation efficiency for effective treatment in herpes infections. The characterization and evaluation of the developed formulation was also carried out.