Endothelialization of gas exchange membranes to provide antithrombogenicity

摘要

In contrast to other studies, the experiments showed successful seeding and static culture of endothelial cells on PMP fibres without previous surface modification. Additionally, even after culture under dynamic conditions, viable cells expressing important proteins for monolayer integrity were found on the unmodified fibres. Nevertheless, dynamic culture of the cells significantly reduced the cell number on the fibres in comparison to static culture conditions, what necessitates modification of the fibre surface for improvement of cell adhesion, even under dynamic conditions, to obtain an anti-thrombogenic endothelial cell monolayer.