Elucidating the Biological Role of Soluble Silicon in Early Bone Mineralisation

摘要

Here we have evaluated the effect of OSA on collagen fibril formation and in vitro mineralisation. Increasing OSA concentration results in the development of a complex collagen fibril network up to supraphysiological OSA concentrations when the fibril network becomes fragmented. TEM images demonstrate that 5μg/ml OSA aids in mineral deposition within collagen fibers.