The Potential Role of Statins in the Regeneration of Osteoporotic Tissue and the Use of Star Degradable Polymers for Controlled Local Delivery

摘要

In this work to date, we have demonstrated the significance of polymer architecture in the degradation of degradable polyesters. The uniform degradation behaviour seen in star PDLLA samples has shown potential for providing controlled drug delivery of statins to local environments in vivo, in attempts to provide anabolic influences in osseous tissues. We are continuing to evaluate these systems and further characterise their behaviour while assessing the response of osteoclasts to the presence of statins in osteoclast-only and in osteoblast-osteoclast co-cultures.