Functional octapeptide hydrogel to bone repair applications

摘要

The incorporation of the RGD motif to the FEFEFKFK peptide sequence, improved the cell spreading, attachment and proliferation of HOBs 3D cultured inside the gel during 14 days. The mechanical properties of the gel allowed to the cells not only proliferate even so, to maintain a sustained production of collagen I, which also was clearly deposited inside gels. Thus, the RGDFEFEFKFK system has potential to be used as 3D scaffold to culture HOBs with regenerative applications.