Combination treatment of hyperthermia and photodynamic for experimental tumor model using gyrotron (107, 203 GHz)

摘要

We had reported the results of application that the terahertz wave irradiation to an experimental transplanted prostate cancer model mouse using the gyrotron. We irradiated the 107 or 203 GHz wave (22.56W/cm2×20 min=27,180 J/cm2), resepectively, against the tumor model BALB-c-nu/nu strain, mail, 12 week old mouse at 43 degree C, which to rising time for 10 min and to keeping the temperature at 43 degree C for 10 min, respectively. The cancer model sizes (axbxcxπ/6 mm3) were measured every day before and after the treatment. In the results, the irradiation anti-tumor effect by the both wave numbers of 203 and 107 GHz for the cancer was found in the case of the transplanted tumor with a cultivated human adenoma cell (PC-3) to decrease more than thousand times comparing the control. In this time, we applied the combination therapy of the hyperthermia treatment using gyrotron and the photodynamic treatment (PDT) with a photosensitizer and laser irradiated the experimental tumor model. It was very good treatment effect although reducing the dose of gyrotron-irradiation before the PDT.