Silica-collagen-calcium phosphate composite materials for bone replacement. In v/fro-manipulation of the ratio of bone forming to bone resorbing cells in a co-culture

摘要

The development of novel materials suitable for bone replacement and tissue engineering is still a major concern in orthopaedic surgery. Among bio-inspired materials, composites consisting of both organic and inorganic phases, have been recognized as promising candidates to accomplish a wide range of requirements. Own previous studies on the templating activity of collagen fibrils during the silica sol-gel process demonstrated the suitability of the system to form macro porous scaffolds with low strength