Design of nanofibrous platforms for bone regeneration by tuning morphological and chemical cues

摘要

Recently, the design and fabrication of complex structural architectures from sub-micronic to nanometric dimensional scale have gained the interest of tissue engineering because of their ability to mimic, geometrically and topologically, the native state of extracellular matrix (ECM) macromolecules in living tissues (i.e. collagen, hyaluronic acid, laminin, and fibronectin) (Ma, 1999). To date, electrospinning represents the more promising technology to realize tailored 2D/3D platforms for tissue regeneration. In particular, this technology enables to satisfy all basic requirements of scaffold design (i.e, high porosity, nanometric scaled fibres, fully pore interconnectivity) through an highly versatile deposition process which may be easily customized to obtain a wide range of micro and nano-structured substrates to use as ECM substitutes (Zhang, 2005).