The majority of thrombi in non-valvular atrial fibrillation (AF) patients are formed in the left atrial appendage (LAA). The shape of the LAA is highly variable and complex morphologies seem to favour the development of thrombus since they may induce blood stasis. Nevertheless, the relation between LAA shape and risk of thrombus has not been rigorously studied due to the lack of appropriate imaging data and robust tools to characterize LAA morphology. The main goal of this work was to automatically extract simple LAA morphological descriptors and study their relation with the presence of thrombus. LAA shape characterization was based on the computation of its centreline combining a heat transfer-derived distance map and a marching algorithm, once it LAA was segmented from 3D medical images. From the LAA centreline, several morphological descriptors were derived such as its length, tortuosity and major bending angles, among others. Other LAA parameters such as surface area, volume and ostium shape parameters were also obtained. A total of 71 LAA geometries from AF patients were analysed; 33 of them with a history of a thromboembolic event. We performed a statistical analysis to identify morphological descriptors showing differences between patients with and without thrombus history. Ostium size and centreline length were significatively different in both cohorts, with larger average values in thromboembolic cases, which could be related to slower blood flow velocities within the LAA. Additionally, some of the obtained centreline-based LAA parameters could be used for a better planning of LAA occluder implantations.
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