A Novel Sample Preparation Method for Quantitative Analysis of Insulin Analogues Using Liquid Chromatography-Tandem Mass Spectrometry

机译：一种新型样品制备方法，用于使用液相色谱 - 串联质谱法定量分析胰岛素类似物的制备方法

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A novel sample preparation method for LC-MS/MS quantitation assay of insulin analogues was developed. The reduction/alkylation step in sample preparation resulted in abundant sequence ions in MS/MS, providing needed specificity and sensitivity for quantitation analysis. Application of the developed method in in vivo PK study was demonstrated.

机译：开发了一种新的样品制备胰岛素类似物的LC-MS / MS定量测定方法。样品制剂中的还原/烷基化步骤得到MS / MS中的丰富序列离子，为定量分析提供所需的特异性和灵敏度。表现出开发方法在体内PK研究中的应用。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2011年||共1页
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Hsuan-shen Chen; Xinchun Tong; Lucinda H. Cohen;
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中图分类 TB994.5-53;
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入库时间 2022-08-21 10:21:54

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A Novel Sample Preparation Method for Quantitative Analysis of Insulin Analogues Using Liquid Chromatography-Tandem Mass Spectrometry

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