Lab on a Chip: a Potential Platform for Point of Care Testing and Drug Screening

摘要

Systematic research on microfluidic especially their potential applications in medical diagnosis and drug screening were carried out in our lab. The chip fabrication capabilities have been extended into design and fabricate chips with higher degree of complexity in different materials, quartz glass, PMMA, PDMS, and hydrogel. A set of methods for surface modification of micro-channels on such materials were developed, which result in better reproducibility and higher efficiency in protein and peptide analysis. Various functional units such as sampling, separation, mechanical pumps/valves, dialysis membrane, SPE (Solid Phase Extraction), PCR reaction, cell culture, sorting and lysis etc were prepared and integrated.