Fabrication And Mechanical Characterization Of Biomorphic Porous Tissue Engineering Scaffolds With Triply Periodic Minimal Surface Geometry

摘要

A scaffold that best mimics the morphology of extracellular matrix- curved, bicontinuous, non-intersecting partitions with minimum mean curvature is an ideal construct for viable cell attachment and proliferation. It is well known that organelles in plant and mammalian cells assume triply periodic minimal surface (TPMS-minimal surfaces with three-dimensional periodicity and zero mean curvature at every point) forms during normal differentiation. However, existing scaffolds based on computer-aided design (CAD) and solid freeform fabrication (SFF) are typically anti-biomorphic and mechanically weak cubic partitions with sharp edges. We introduce TPMS based unit cells to create biomorphic scaffolds with optimal stress/strain distribution and superior mechanical strength.