OXIDATIVE DAMAGE CAUSED BY AIR FORMALDEHYDE EXPOSURE IN ORGANS OF MICE

摘要

Few researches concern about oxidative damage of inhaled formaldehyde in medium or low concentrations. Therefore, we treated three groups of mice with 1.0 mg/m{sup}3, 3.0 mg/m{sup}3 formaldehyde and the control group inhaled fresh air. All of the mice were treated 6 hours per day for 10 days. After exposure, the activities of total superoxide dismutase (SOD), content of glutathione (GSH) and malondialdehyde (MDA) in five organs-brain, heart, lung, liver and kidney were measured. The results showed that inhaled formaldehyde caused the obvious decrease of SOD activities in five organs (P<0.01) in 3.0 mg/m{sup}3 group, and the level of GSH in all treated groups were decreased significantly in various organs (P<0.05) compared with fresh air group. The level of MDA in all organs of 3.0 mg/m{sup}3 were increased significantly (p<0.05) compared with fresh air group. In conclusion, medium concentration formaldehyde gas induces significantly oxidative damage of various organs.