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Stability of Rearrangement Measures in the Comparison of Genome Sequences

机译:基因组序列比较中重排措施的稳定性

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We present data-analytic and statistical tools for studying rates of rearrangement of whole genomes and to assess the stability of these methods with changes in the level of resolution of the genomic data. We construct data sets on the numbers of conserved syntenies and conserved segments shared by pairs of animal genomes at different levels of resolution. We fit these data to an evolutionary tree and find the rates of rearrangement on various evolutionary lineages. We document the lack of clocklikebehaviour of rearrangement processes, the independence of translocation and inversion rates, and the level of resolution beyond which translocations rates are lost in noise due to other processes.
机译:我们呈现数据分析和统计工具,用于研究整个基因组重排的率,并评估这些方法的稳定性随着基因组数据的分辨率水平的变化。我们构建数据集关于在不同分辨率分别的动物基因组对共享的保守同步和保守段的数量。我们将这些数据符合进化树,并找到各种进化谱系的重排率。我们记录了重排过程的缺乏时钟,易位和反转速率的独立性,以及由于其他过程噪声损失的分辨率损失的分辨率水平。

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