PERFORMANCE OF POLYMERIC SCAFFOLDS IN TISSUE ENGINEERING

摘要

Polymeric scaffolds in tissue engineering provide temporary mechanical support for tissue regeneration while shaping the in-growing tissues. The overall stiffness of the polymer-tissue constructs in bone/cartilage tissue engineering can affect the tissue in-growth by altering the local mechanical environment around the cells. This work deals with the influence of scaffold material properties on its load-bearing characteristics. Moreover, it demonstrates the role of scaffold porosity on the load dissipation through drag forces based on a biphasic model. The final goal of this work is to improve the performance of hybrid bone/cartilage polymeric scaffolds.