Postprocedural increase of serum IL-2R level predicts the restenosis after intracoronary implantation of bare metal stents

摘要

Alongside mechanical factors, the local and systemic inflammation, formed as a ?response to injury"after percutaneous coronary intervention (PCI), has a very important part in developing restenosis(1).Following the successful PCI, persistent elevation of the systemic markers of inflammation has been associated with a poor prognosis(1). On the opposite side, the antithrombocitic drugs and the GP inhibitors decrease the inflammatory response and procoagulatory state, which favours the prognosis after the intervention (1,2).The mechanical injury of the coronary artery causes the very strong inflammatory response and production of the grow factors and cytokines, both from the inflammatory cells attracted from the peripheral blood and also form the activated vascular cell(1).